<chemical> 3-benzoyl-alpha-methylbenzeneacetic acid. An ibuprofen-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.
Pharmacological action: non-steroidal anti-inflammatory agents, cyclooxygenase inhibitors.
Chemical name: Benzeneacetic acid, 3-benzoyl-alpha-methyl-
(12 Dec 1998)
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Ketoprofen
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| Systematic (IUPAC) name | |
| 2-(3-benzoylphenyl)propanoic acid | |
| Identifiers | |
| CAS number | |
| ATC code | M01 M01, M02 |
| PubChem | |
| Drug |
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| Chemical data | |
| Formula | C16H14O3 |
| Mol. mass | 254.281 g/mol |
| Pharmacokinetic data | |
| Bioavailability |
? |
| Protein binding | 99% |
| Metabolism | ? |
| Half life | 2-2.5 hours |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
C (D in 3rd trimester) |
| Legal status |
POM |
| Routes | ? |
Ketoprofen, (RS)2-(3-benzoylphenyl)-propionic acid (chemical formula C16H14O3) is one of the propionic acid class of Non-steroidal anti-inflammatory drug
Ketoprofen was available over-the-counter in the United States in the form of 12.5 mg coated tablets (Orudis KT & Actron), but the product has been discontinued, due to lack of consumer demand. It is available by prescription as 25, 50, 75, 100, 150, and 200 mg capsules.
Ketoprofen also comes in a 2,5% gel for Topical
Brand names in the US are Orudis and Oruvail. It is available in the UK as Ketoflam and Oruvail, in Finland as Ketorin, in France as Bi-Profnid, in Italy as Fastum Gel or Ketoprofene, in Poland as Ketonal and Norway as Zon or Orudis.
In Lithuania, Ketoprofen is called Ketoprofenum and/or Ketoprofenas. For topical application: the name brands are Fastum with 2.5% (gel) which is over the counter and Ketospray with 10% (liquid spray) which must be prescribed. In Switzerland, and innovative ketoprofen formulation based on Transfersome
In some countries, the optically pure (S)-enantiomer (dexketoprofen) is available; its trometamol salt is said to be particularly rapidly reabsorbed from the gastrointestinal tract, having a rapid onset of effects.
Ketoprofen is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums.
Ketoprofen (Ketofen) is a common NSAID, antipyretic, and analgesic used in horses and other equines. It is also used as a mild painkiller in smaller animals, generally following surgical procedures. It is most commonly used for muscoskeletal pain, joint problems, and soft tissue injury, as well as laminitis. It does not treat the underlying problem, nor does it speed the healing process. It is also used to control fevers and prevent endotoxemia. However, they may mask the symptoms of the underlying problem, and therefore make diagnosis more difficult for a veterinarian.
Side effects are relatively uncommon if used as recommended, and less common than 2 other commonly used NSAIDs: flunixin or Phenylbutazone
Additionally, it should not be used in horses allergic to Aspirin
Ketoprofen should not be used in with other NSAIDs or corticosteroids, as this increases the risk of GI ulceration. It should also be used with caution with other anticoagulants. It is commonly used with omeprazole, sucralfate, and cimetidine to help protect the GI tract.
Ketoprofen is labeled to be administered intravenously only, and is recommended for a maximum of five days of use. Its analgesic and antipyretic effects begin to occur 1-2 hours following administration. The most common dosage is 1 mg/lb, once per day, although this dosage may be lowered for ponies, who are most susceptible to NSAID side effects.
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