Proteins released by sensitised lymphocytes and possibly other cells that inhibit the migration of macrophages away from the release site. The structure and chemical properties may vary with the species and type of releasing cell.
(12 Dec 1998)
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Macrophage migration inhibitory factor (glycosylation-inhibiting factor)
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| PDB rendering based on 1ca7. | ||||||||||||||
| Available structures: 1ca7, 1cgq, 1gcz, 1gd0, 1gif, 1ljt, 1mif, 1p1g, 2ooh, 2oow, 2ooz | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbols | MIF; GIF; GLIF; MMIF | |||||||||||||
| External IDs | OMIM: 153620 MGI: 96982 HomoloGene: 55655 | |||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 4282 | 17319 | ||||||||||||
| Ensembl | ENSG00000099964 | n/a | ||||||||||||
| Uniprot | P14174 | n/a | ||||||||||||
| Refseq | NM_002415 (mRNA) NP_002406 (protein) |
NM_010798 (mRNA) NP_034928 (protein) |
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| Location | Chr 22: 22.37 - 22.57 Mb | n/a | ||||||||||||
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Macrophage migration inhibiting factor (MIF) is an inflammatory mediator associated with Rheumatoid Arthritis
This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways.[1]
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