Shy-Drager syndrome

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Definition from OMD (Online Medical Dictionary):

shy-drager syndrome

<syndrome> A progressive degenerative disease of the central and autonomic nervous systems characterised by orthostatic hypotension, urinary and faecal incontinence, anhidrosis, external ophthalmoplegia, generalised weakness, muscle wasting, tremors, and impotence.

(12 Dec 1998)

Shy-Drager syndrome Classification and external resources
ICD-10	G90.3
ICD-9	333.0
DiseasesDB	12042
MeSH	D012791

Shy-Drager syndrome is a rare, progressively degenerative disease of the autonomic nervous system. It is named after Dr Milton Shy and Dr Glenn Drager, who identified this syndrome in 1960.^[1]^[2]

The American Autonomic Society and the American Academy of Neurology deprecated it as a disease entity in 1996,^[3] and existing cases were redefined as multiple system atrophy with autonomic phenomena. The name "Shy-Drager syndrome" is still used occasionally for Multiple system atrophy when the primary symptoms are autonomic failure.

Symptoms

Problems with the autonomic nervous system, such as dysphagia, incontinence, hypotension (specifically orthostatic hypotension), gastroparesis, and erectile dysfunction, among others (see autonomic neuropathy).
Parkinsonian symptoms
Other nonspecific neurologic symptoms such as ataxia and pyramidal symptoms^{[citation needed]}

Treatment

No definitive treatment currently exists. Medication s used for Parkinson's disease have not shown to be useful. Treatments are generally geared to give symptomatic control, especially to maintain adequate blood pressure (adrenergic agonists, and mineralocorticoid analogs such as fludrocortisone).^{[citation needed]}

Notable sufferers

Johnny Cash (possible misdiagnosis of autonomic neuropathy)^{[citation needed]}

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